High-THC Cannabis & Mental Health Journal Club May 2026

Written By Jahan Marcu, PhD

Join us for an upcoming journal club where we will examine a recent systematic review from Annals of Internal Medicine: “High-Concentration Δ9-THC Cannabis Products and Mental Health Outcomes”

This review synthesizes 99 studies (n=221,097 participants) and explores associations between high-THC products and outcomes including:

  • Anxiety

  • Depression

  • Psychosis / schizophrenia

  • Cannabis use disorder

Key themes we’ll discuss:

  • The consistent signal: stronger associations with psychosis and CUD

  • The paradox: therapeutic vs. non-therapeutic contexts

  • The problem of bias, heterogeneity, and real-world translation

  • What “high potency” actually means—and whether that definition holds up

Time: May 5th, 2026 Noon EST     

Location – Virtual Meeting
https://us02web.zoom.us/j/83722922366?pwd=QjZ3V0xNWHZ0OVZ0b3BpbWd3STRqUT09

Link to Paper:

https://pubmed.ncbi.nlm.nih.gov/40854216/

Speakers:

  • Phil Molloy, MD – Clinical education expert

  • Teresa Simon, MPH – Public health epidemiologist

  • Len Kamen, MD – Clinical pain specialist

  • Jahan Marcu, PhD – Cannabis researcher

Questions? Email Prctrials.info@gmail.com

This journal club event is supported by PRC+. PRC + has education modules and other resources available for health care professionals: https://www.prc-trials-plus.com/education

Jahan Marcu, PhD
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